粉防乙碱;汉防己硷 Tetrandrine
交易须知
tetrandrine产品活性：tetrandrine (nsc-77037) 是一种双苯基异喹啉生物碱，抑制电压门控钙离子通道 (ica) 和 ca2+ 激活的钾离子通道。
研究领域：membrane transporter/ion channel
作用靶点：calcium channel | potassium channel
in vitro: the effects of tetrandrine (nsc-77037), a bis-benzyl-isoquinoline alkaloid, on voltage-gated ca2+ currents (ica) and on ca2+-activated k+ current (ik(ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. the non-inactivating component of ica is inhibited by external tetrandrine (nsc-77037) in a voltage- and dose-dependent manner, with an ic50=10.1μm. tetrandrine (nsc-77037) decreases the channel-open probability, within bursts, with an ic50=0.21 μm. to evaluate the effects of tetrandrine on hcc cells, huh7, hcclm9 and hep3b cells are treated with 0 (dmso), 0.5, 1, 2 or 4 μm of tetrandrine for 24 h. the cell proliferation assay indicates that tetrandrine exhibits almost no effect on the inhibition of hcc cell proliferation at 0.5-2 μm. however, tetrandrine (nsc-77037) inhibits hcc cell migration in a dose-dependent manner. furthermore, a wound-healing and transwell assay shows that 2 μm tetrandrine significantly inhibits hcc cell migration and invasion.
in vivo: to evaluate the effect of tetrandrine (nsc-77037) on the inhibition of tumor metastasis in vivo, hcclm9 subcutaneous tumor xenograft models is established with athymic nude mice. when the tumor volume reach approximately 50 mm3, nude mice are orally administered vehicle or tetrandrine (nsc-77037) (30 mg/kg) every other day for 37 days. tetrandrine (nsc-77037) treatment inhibits tumor growth by reducing the tumor volume and weight.
相关产品：fda-approved drug library plus | drug repurposing compound library plus | bioactive compound library plus | nigericin sodium salt | neomycin sulfate | verapamil hydrochloride | chlorpromazine hydrochloride | nifedipine | ionomycin | senicapoc | thapsigargin | acetylcholine chloride | glibenclamide | e-4031 | 4-aminopyridine | mibefradil dihydrochloride | ginsenoside rg3 | dofetilide | nimodipine | 20-hete | bay-k-8644 ((s)-(-)-) | cdn1163 | pap-1 | diltiazem hydrochloride | tolbutamide | amiodarone hydrochloride | minoxidil | tram-34 | dantrolene sodium hemiheptahydrate | diazoxide | flufenamic acid | ns-1619 | terfenadine
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粉防乙碱;汉防己硷 Tetrandrine
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tetrandrine产品活性：tetrandrine (nsc-77037) 是一种双苯基异喹啉生物碱，抑制电压门控钙离子通道 (ica) 和 ca2+ 激活的钾离子通道。
研究领域：membrane transporter/ion channel
作用靶点：calcium channel | potassium channel
in vitro: the effects of tetrandrine (nsc-77037), a bis-benzyl-isoquinoline alkaloid, on voltage-gated ca2+ currents (ica) and on ca2+-activated k+ current (ik(ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. the non-inactivating component of ica is inhibited by external tetrandrine (nsc-77037) in a voltage- and dose-dependent manner, with an ic50=10.1μm. tetrandrine (nsc-77037) decreases the channel-open probability, within bursts, with an ic50=0.21 μm. to evaluate the effects of tetrandrine on hcc cells, huh7, hcclm9 and hep3b cells are treated with 0 (dmso), 0.5, 1, 2 or 4 μm of tetrandrine for 24 h. the cell proliferation assay indicates that tetrandrine exhibits almost no effect on the inhibition of hcc cell proliferation at 0.5-2 μm. however, tetrandrine (nsc-77037) inhibits hcc cell migration in a dose-dependent manner. furthermore, a wound-healing and transwell assay shows that 2 μm tetrandrine significantly inhibits hcc cell migration and invasion.
in vivo: to evaluate the effect of tetrandrine (nsc-77037) on the inhibition of tumor metastasis in vivo, hcclm9 subcutaneous tumor xenograft models is established with athymic nude mice. when the tumor volume reach approximately 50 mm3, nude mice are orally administered vehicle or tetrandrine (nsc-77037) (30 mg/kg) every other day for 37 days. tetrandrine (nsc-77037) treatment inhibits tumor growth by reducing the tumor volume and weight.
相关产品：fda-approved drug library plus | drug repurposing compound library plus | bioactive compound library plus | nigericin sodium salt | neomycin sulfate | verapamil hydrochloride | chlorpromazine hydrochloride | nifedipine | ionomycin | senicapoc | thapsigargin | acetylcholine chloride | glibenclamide | e-4031 | 4-aminopyridine | mibefradil dihydrochloride | ginsenoside rg3 | dofetilide | nimodipine | 20-hete | bay-k-8644 ((s)-(-)-) | cdn1163 | pap-1 | diltiazem hydrochloride | tolbutamide | amiodarone hydrochloride | minoxidil | tram-34 | dantrolene sodium hemiheptahydrate | diazoxide | flufenamic acid | ns-1619 | terfenadine
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
正品 花之溢 玫瑰酒香薰精华浴50ml
高分子加工件材质
新闻:苏市沥青瓦
江苏省淮阴区街舞知识大全
供应KLQ燃气烤炉 五香花生米烘烤机 花生果核桃板栗烘烤机
粉防乙碱;汉防己硷 Tetrandrine
双挑式滑触线集电器怎么选型？
新申亚麻大师 | 亚麻相伴，更清凉的夏天来了。
现货供应JYSC单头加长臂鸡眼机【自动下料 快速装订】
包税进口收费价格？博时通运 成本低服务好
2018中国(雄安)地坪工业展览会
福朋酒店加盟费多少
惠安瑜伽：头倒立的时候，你的口腔状态是怎么样的
眼下做什么生意有前景?加盟代理酒神杜康白酒前景无限
印尼签证办理咨询 移民政策解读 骏棹移民咨询知名度高
厂家生产日标带颈平焊法兰
10方压缩式垃圾车
曲阳雕刻厂家介绍景观雕塑对我们日常生活的影响
供应涂料增稠剂 厂家直销涂料增稠剂 低价格涂料增稠剂
50吨全自动无塔供水设备可定制 开封高地